Select publications featuring FANA ASO Technology
2021
Joshua M. Corbin, Constantin Georgescu, Jonathan D. Wren, Chao Xu, Adam S. Asch, Maria J. Ruiz-Echevarría. (2021). SEED-MEDIATED RNA INTERFERENCE OF ANDROGEN SIGNALING AND SURVIVAL NETWORKS INDUCES CELL DEATH IN PROSTATE CANCER CELLS. Mol Ther Nucleic Acids. 24:337-351.
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Nicolas Pelisch, Jose Rosas Almanza, Kyle E. Stehlik, Brandy Aperi and Antje Kroner. (2021) Use of a self-delivering Anti-CCL3 FANA Oligonucleotide as an innovative approach to target inflammation after Spinal Cord Injury. eNeuro. DOI: https://doi.org/10.1523/ENEURO.0338-20.2021
2020
Yen-Ruh Wuu, Burong Hu, Hazeem Okunola, Amber M Paul, Elizabeth A Blaber , Margareth Cheng-Campbell, Afshin Beheshti, Peter Grabham. Let-dependent low dose and synergistic inhibition of human angiogenesis by charged particles: validation of miRNAs that drive inhibition. iScience. https://doi.org/10.1016/j.isci.2020.101771 (2020).
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Rasika P. Harshe, Anyan Xie, Marta Vuerich, Luiza Abrahão Frank, Barbora Gromova, Haohai Zhang, Rene’ J. Robles, Samiran Mukherjee, Eva Csizmadia, Efi Kokkotou, Adam S. Cheifetz, Alan C. Moss, Satya K. Kota, Simon C. Robson & Maria Serena Longhi. (2020) Endogenous antisense RNA curbs CD39 expression in Crohn’s disease. Nature Communications. 11:5894
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Shytaj, I. L., Lucic, B., Forcato, M., Penzo, C., Billingsley, J., Laketa, V., Bosinger, S., Stanic, M., Gregoretti, F., Antonelli, L., Oliva, G., Frese, C. K., Trifunovic, A., Galy, B., Eibl, C., Silvestri, G., Bicciato, S., Savarino, A., & Lusic, M. (2020). Alterations of redox and iron metabolism accompany the development of HIV latency. The EMBO journal, 39(9), e102209.
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Margiotta Joseph F. and Howard Marthe J. (2020). Cryptochromes Mediate Intrinsic Photomechanical Transduction in Avian Iris and Somatic Striated Muscle. Frontiers in Physiology. 11:(128)
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Naimesh Solanki, Tomilowo Abijo, Carine Galvao, Philippe Darius, Kenneth Blum, Marjorie C. Gondré-Lewis. (2020). Administration of a putative pro-dopamine regulator, a neuronutrient, mitigates alcohol intake in alcohol-preferring rats. Behavioural Brain Research, https://doi.org/10.1016/j.bbr.2020.112563
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Karyn Schmidt, Chase A. Weidmann, Thomas A. Hilimire, Elaine Yee, Breanne M. Hatfield, John S. Schneekloth, Kevin M. Weeks, Carl D. Novina. (2020). Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. Cell Reports. 30(2):541-554.e5
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Francesco D. Valle, Manjula P. Thimma, Massimiliano Caiazzo, Salvatore Pulcrano, Mirko Celii, Sabir A. Adroub, Peng Liu, Gregorio Alanis-Lobato, Vania Broccoli, Valerio Orlando. (2020). Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2019.12.002
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N. Souleimanian, G.F. Deleavey, H. Soifer, S. Wang, K. Tiemann, M.J. Damha and C.A. Stein (2012), Antisense 2′-deoxy-2′-fluoroarabinonucleic acids (2′F-ANAs) antisense oligonucleotides: in vitro gymnotic silencers of gene expression whose potency is enhanced by fatty acids, Molecular Therapy-Nucleic Acids, Sep 18; 1:e43; doi: 10.1038/mtna.2012.35.
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FANA oligos are resistant to degradation by serum and cellular nucleases and exhibit greater potency and stability
A. Dudley, M. Sater, P.U. Le, G. Trinh, M.S. Sadr, J. Bergeron, G.F. Deleavey, B. Bedell, M.J. Damha and K. Petrecca (2014) DRR regulates AKT activation to drive brain cancer invasion, Oncogene, 33:4952-60
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N. Ferrari, D. Bergeron, A.-L. Tedeschi, M.M. Mangos, L. Paquet, P.M. Renzi and M.J. Damha (2006) Characterization of antisense oligonucleotides comprised of 2′-deoxy-2′-fluoro-b-D-arabinonucleic acid (FANA): specificity, potency and duration of activity, Annals of the New York Academy of Sciences, 1082: 91–102.
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A. Kalota, L. Karabon, C Swider, E. Viazovkina, M. Elzagheid, M.J. Damha and A. Gewirtz (2006) 2′-Deoxy-2′-fluoro-b-D-arabinonucleic acid (2′F-ANA), modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing, Nucleic Acids Research, 34: 451-461.
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FANA sugar modification significantly enhances chemical stability
J.K. Watts, A. Katolik, J. Viladoms and M.J. Damha (2009), Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′F-ANA), Organic & Biomolecular Chemistry, 7:1904 – 1910.
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FANA sugar modification significantly enhances intracellular stability
A. Kalota, L. Karabon, C Swider, E. Viazovkina, M. Elzagheid, M.J. Damha and A. Gewirtz (2006) 2′-Deoxy-2′-fluoro-b-D-arabinonucleic acid (2′F-ANA), modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing, Nucleic Acids Research, 34: 451-461.
N. Ferrari, D. Bergeron, A.-L. Tedeschi, M.M. Mangos, L. Paquet, P.M. Renzi and M.J. Damha (2006) Characterization of antisense oligonucleotides comprised of 2′-deoxy-2′-fluoro-b-D-arabinonucleic acid (FANA): specificity, potency and duration of activity, Annals of the New York Academy of Sciences, 1082: 91–102.