Self delivering FANA antisense oligonucleotide technology for basic, translational and pre-clinical research
1) GENE SILENCING / KNOCKDOWN
AUMsilence self delivering oligos achieve highly efficient and potent antisense-based gene knockdown. No need to use toxic transfection reagents. Especially designed for primary cells and very difficult to transfect cell types. Ideal for animal studies. Suited for fish and amphibian model systems as well.
Highly recommended as a replacement for siRNAs or other oligonucleotide approaches.
2) microRNA REGULATION AND MODULATION
AUMantagomir self transfecting oligos serve as potent antagomirs by binding with miRNAs and prevent their hybridization with their target mRNAs.
AUMmirblocker self transfecting oligos serve as competitive blockers/decoys against miRNAs to inhibit their binding with target mRNA.
AUMmirblocker oligos will bind with the targeted regions on the mRNA
and inhibit binding of miRNA with the mRNA.
3) Long non-coding RNA REGULATION
AUMlnc oligos achieve potent RNase H-mediated cleavage of the target long non-coding RNA.
4) EXON SKIPPING
AUMskip oligos make suitable candidates for exon skipping experiments.
5) SPLICING MODULATION
AUMsplice oligos make suitable candidates for splicing modulation experiments
6) DECOYS, BLOCKERS AND PROBES
AUMblock oligos act as steric blockers and inhibit translation elongation. AUMblock oligos act as decoys and repress protein expression and do not induce mRNA cleavage.
AUMprobes serve as excellent probes or decoys to suit a wide variety of experimental applications.